*This website DOES NOT constitute treatment and only provides information and advice. For treatment (therapy and/or medications) you must go to a licensed professional in your area. Please note that anything said here is not private or confidential, as this is a public forum. Hello, I am very sorry that you are feeling depressed right now, I can understand how distressing this can be for you. It is of course possible that you can become tolerant to the Wellbutrin as that is not uncommon with long-term use of any antidepressant. May I ask, what is the daily dosage of the Wellbutrin that you take?