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You have been given these two medications to manage a specific disorder, and your physician or psychiatrist has determined the proper dosages for each, and the interactions in order to best help you.
Certain elements in Geodon react negatively with grapefruit juice. The combination may interact to increase the strength of the Geodon, but may also decrease the strength or cause unwanted physical or mental side effects.
There is a warning with Geodon NOT TO TAKE GRAPEFRUIT JUICE with it, and I believe that you should heed this warning.
Actually, there is a high risk warning about taking fluoxetine and Geodon (ziprasidone) together, on www.drugs.com
Applies to: XXXXXXXXXX, XXXXXX (ziprasidone)
Using ziprasidone together with FLUoxetine is not recommended. Combining these medications can increase the risk
Here is the link. You should alert your physician:
St. John's Wort also can control your depression, but is generally not as powerful as fluoxetine. However, unlike fluoxetine it is NOT contraindicated (bad reaction) with Geodon.
You should talk to your physician about giving you a more powerful antidepressant, such as mirtazepine, which will not react negatively with St. John's Wort, if the SJW is not effective for you.
If the SJW is helping and you have already made the transition from fluoxetine to SJW, then there should be no problem.
However, follow the scientific/medical wisdom and avoid the grapefruit juice. You are only rising unwanted negative side effects.
I wish you great success and shall keep you in my prayers.
Elliott, MAE, LPCC, NCC, CCMHC