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I shall be happy to help you with this question.
Please give me a moment.
Quetiapine's measurement of dissipation from the body is measured in the same terms as any other medications, by a concept known as half life.
A half-life is a measurement of the TIME that it takes for a set amount of the medication from the time of absorption into the body to by reduced by half (by 50%).
So let us say that you had 100 mg.of quetiapine. It would take tale 6 hours (for IR or immediate release) or 7 hours (for ER or extended release) to be reduce to half or 50 mg. in the body
After another 6 (or 7 for ER) hours it would be reduced by half again, so there would be 25 mg. remaining.
After another 6 (or 7) hours there would be about 12.5 mg remaining.
After another 6 (or 7) hours there would be about 6.25 mg. remaining.
So you see, it is getting less and less by half every 6 (or 7) hours..
So you see, that after awhile the effective amount becomes insignificantly small.
I believe that his answers your question. It you have a follow-up, please be sure to get back to me.