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Hello I believe I can help you with your concern
I am sorry that you have been experiencing these symptoms associated with anxiety and dysthymia, I can imagine how distressing this is for you
Serzone was a very potent antidepressant that was effective, but it also caused severe liver damage in some patients and that is why it was taken off the market.
May I ask, how long have you been diagnosed with dysthymia and anxiety disorders for?
Serzone is 5-HT2a antagonist, so you may get benefits from another 5-HT2a antagonist, like Valdoxan, which I believed was approved for use in Canada in 2009. Seroquel XR also has 5-HT2a antagonist properties as well
How has the Trazadone been working for you so far?
In addition, adding Abilify to an antidepressant can be beneficial as well. Abilify has been shown to increase the effectiveness of antidepressants in recent studies and you can take it along with the Trazadone if you feel the Trazadone has been effective for you.
Also Serzone has a moderate affinity to the 5-HT1a receptor as well, so it is possible that Buspar or Viibryd could be beneficial for you as well as these medications are partial agonists for this receptor.
Serzone actually had a low affinity for Serotonin, norepinephrine, and dopamine receptors, so this could explain why the SSRI and NDRI (e.g. Wellbutrin) medications were not effective for you and why the SNRI and NRI medications may not be as beneficial for you because your symptoms respond better to medications that target the 5-HT2a, 5-HT1a, adrenergic receptors. This is most likely why the Serzone was so effective for you.
I see that you are offline right now, but when you get back online I would be very interested in continuing this discussion with you and talking about anything further you would like to share regarding your concern, so if you respond in the chat box I will be able to get back to you as soon as possible.
I am sorry, I can imagine that feeling a chronic depressive disorder like dysthymia at such a young age would make you feel like it was normal because you had nothing to compare it to. But I am glad that you are seeking treatment for it since. I believe your question was cut off you started to say "What does low" and then it was cut off
The Abilify attaches to key receptors like the antidepressant and enhances the antidepressant's effectiveness in this way. The Valdoxan is a 5-HT2a antagonist like the Serzone, so that is why I thought it would be a good replacement medication for the Serzone you tried years ago.
Valdoxan is still relatively new and not prescribed a lot, but I believe you can bring it up with your prescribing physician since it is a major 5-HT2a antagonist like your Serzone
Well Seroquel does have those effects as well, but not as strongly as the Serzone did or the Valdoxan. So 5ht2a, 5ht1a adrenergic receptors are neurotransmitter sites in your brain that effect your mood. So those medications react mainly with those neurotransmitters that I mentioned in your brain to help lessen your symptoms
In addition, Trimipramine is also a strong antagonist for the 5ht2a receptor like Serzone, so that could be effective for you as well. So in my opinion I would ask about Valdoxan and Trimipramine first, and see if that helps relieve your symptoms. You should start to see benefits in 2-3 weeks and then maximum benefits in 6-8 weeks
If those two medications do not work then you can try adding abilify to one of your antidepressants that you believe you had the most success with to enhance its effectiveness for you. But I believe you will find success with Valdoxan and Trimipramine as these medications are so closely similar to the Serzone
Valdoxan and Trimipramine is available in Canada and they are actually called 5-HT2a antagonist antidepressants, same class as the Serzone was. The Valdoxan is much more recent and supposedly has much less side effects than the Trimipramine
Because Valdoxan is new, some doctors are not familiar with it, so you will have to bring it up with the doctor
And definitely mention how Serzone worked for you in the past and how Valdoxan is a similar class medication
No actually Trazadone is in the Serotonin antagonist and reuptake inhibitors class (SARI) and has a strong connection with serotonin like most antidepressants. Serzone worked differently and did not have a strong connection with Serotonin. Serzone was 5-HT2a antagonist receptor class antidepressant
I am sorry I mistyped, Trazadone did work by blocking Serotonin lreuptake like Serzone, but it did not effect the 5-HT2a antagonist like the Serzone and that is what makes them inherently different
For some reason I thought you mentioned Thorazine and that is why I was mistyped.
I still think the Valdoxan would be a good choice over the Trazadone because of it 5-HT2a antagonist profile like Serzone.
Unfortunately psychotropic medications are not an exact science because every body reacts differently to the medications, so trying to find the right combination of medications may take some trial and error approach
Yes dysthymia is often called a less severe form of depression because it usually does not have as severe symptoms as a major depressive disorder, but I feel is a very severe depressive disorder due to its chronic nature and feelings of hopelessness commonly attached to it.
It is also a difficult disorder to treat as well due to the chronic nature of it
Pristiq works mostly on serotonin and norepinephrine, so it will not have strong binds to those receptors that the Serzone has binds to. Many antidepressants work well for anxiety, but not all of them. Also anxiety and depression often co-occur (around 60-65 percent of the time do they occur together) so it is possibly that when your dysthymia symptoms lessen, so will your anxiety symptoms and that is probably why the Serzone worked so well. Yes many individuals do find the need to take a benzodiazepine in conjunction with an antidepressant if their anxiety is moderate to severe, so you can continue to take the Ativan if you wish and if it is still beneficial to you
In addition, if the medication is not working you may also want to try Transcranial Magnetic Stimulation (TMS). Which has shown in some studies to be effective in treating resistant depressive disorders
Here are couple links describing it
It does effect melatonin, so there are no insomnia or day time sleep effects associated with this medication. So this medication will actually improve your sleep quality
Well like I said this medication is new, it will get approval in the United States later this year or possibly early next year, and it has been allowed in Canada since 2009, and yes there have been some positive results from studies that show its effectiveness.
Here is a study about Valdoxan for you
Also that author wrote another study on it as well, not sure if it is very different, but I want to give you everything I have.
It is my pleasure, I am happy to help you today and I truly hope this medication is the key in helping you
I actually do not have your email, only the administrators do, but I can follow up using the Q&A format after you rate me and post anything that I think would be helpful for you
Is there anything else I can assist you with today?
Here is one last study for you too
Sorry I am big nerd on studies
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Well all you have to do is put "For Doctor Z only" to ask another question, but if you have follow up questions on this matter, you can ask me them for free at anytime. You should have a link in your email to this chat, so you can click on that and ask me follow up questions for free at anytime in the future.
Good bye and good luck :)