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The literature that comes with both of those medications will tell you that effects often do not start for several weeks which is true.
I have dealt with many people taking both of those medications and others such as celexa, etc. and a large percentage feel much better after a couple of doses and then the effects drop off for several weeks. After the body adjust to the medication the mood stabilizes and this is often at around 6-10 weeks of taking it. The initial effect in the short term is almost like a "high" and you are not alone in feeling this.
As you get closer to the 6-10 week period feeling nauseous is not uncommon but this does pass if you will stick with it and the body will stabilize serotonin levels.
Initially the serotonin levels begin to rise rapidly since the drug stops it from being eliminated and that is the cause for the mood elevation and energy spike.
Ok, but in the case of Pristiq, it was almost 7-8 weeks into the dosage before it began to work, this wasn't a high I experienced in the first few weeks.
Yes but this is still the same principle just an altered timeline. The full effects and normalization does not occur until 6-10 weeks depending on the person. Due to the increase of serotonin and the body adjusting to this new "normal".
You do have to remember also though that not all people have the same effects with a particular ssri and this one may not be the one right for you.
However, you should stick with it for at least 10 weeks to see how you feel.
If it is not effective or you continue to feel ill there are many others out there. Sometimes the latest and greatest is not the right choice.
I know if is an uncomfortable feeling and that you want to feel "right" immediately but unfortunately this takes time.
I want a response from a qualified psychiatrist, not a nurse.
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What can you suggest to augment an SSRI medication? I find that the medication works, but very quickly stops working. I am going to try Prozac, but I'm expecting something similar to happen, where the medication kicks in, but stops working shortly after. Right now, I'm at 9 weeks with Pristiq 100mg, and it's making me feel a little ill in the stomach, and I just feel 'out of it'. A few weeks ago I didn't feel like this at all, I had the occasional side effect, but nothing like this.
Is it possible that I need to take a medication that works on dopamine as well? As far as I know pristiq works on Serotonin + norepinephrine, but it is mostly Serotonin at the lower dosages.
Hello, Thanks for your reply. Bupropion (Wellbutrin)and Mirtazapine (Remeron) are two such medicines which can be used to augment the antidepressant effect of SSRI antidepressant like Prozac, Lexapro, or Zoloft. Bupropion is specially useful in patients who have additional symptoms like fatigue, lack of concentration, excessive sleepiness, lethargy etc. Being an activating antidepressant it is usually prescribed in morning time. It does not cause weight gain and can even counteract the sexual side effects due to SSRI antidepressant if any. [Bupropion mainly works on Dopamine receptors.] Mirtazapine is specially useful in patients complaining of insomnia and lack of appetite. It can also counteract the sexual side effects as well as gastrointestinal side effects due to SSRI antidepressant if any. It can cause weight gain in some patients and is usually prescribed at night. My goal is to provide you with excellent service and I hope I’ve provided the information you were seeking, if not, please let me know so that l can continue to help you. If you need more help, please use the reply tab to continue our conversation. If you do not require further assistance,please rate one of the positive ratings (3,4,5 / smiley faces) as this is the only way how we are compensated for our time and expertise. Please take a moment to rate the answer. Kind regards Vikas