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Thanks for your response. I had company which is why it took me so long to get back to you. I did actually try what you suggested before and not great but my options are limited. I was on effexor in the past and would never take it again. Coming off was awful!!. i am also on celexa 20 mg qd which is available in liquid form. A psych colleague called me and told me i shouls still take the wellbutrin 300 xl qd and dissolve in water. What are your thoughts on that?
Well, given your bad experience with Effexor (very common problem with it, the one you mentioned!), that leaves Cymbatla or Pristiq as options on the SNRI class. Cymbalta cannot be chewed, crushed, or placed in liquid, so that one is out. Pristiq is fairly small and might be cut up into smaller pieces, but I have not had a lot of patients do well on it, so there is that as a counterpoint.
I agree that staying on the Wellbutrin XL 300 mg, if possible, is the most desired option. It has been the medication to work well for you. You can dissolve it in water, but my guess is it won't taste any better than the 100 mg pills.
So, if you want to stay with the Wellbutrin option, try the same ideas listed above. Another creative one is to cut the pill into smaller pieces (but not dissolve it in water) and try to down it with something potent, such as Nyquil (not necessarily Nyquil! Just something obnoxious that wil distract you from the taste and let you get the medicine down.
There's always the G-tube option! (I'm not serious, of course)
Please let me know if you have other questions!