Seeking expert counseling is a sign of strength. A personal relationship with a caring professional is proven clinically effective.
There are several things that may have affected your wife's behavior. Sometimes Zoloft can cause hypomania (a lower grade of mania). Also, if your wife did have some bipolar
disorder to begin with, and her depression was not unipolar but bipolar depression (the depressive side of bipolar disorder (formerly called manic depression), then an antidepressant alone can cause the patient to have a strong manic reaction, hence the Abilify.
You physician sounds as if he is competent and intelligent. You might, however, make an appointment to see a psychiatrist, who is an expert on psychotropic drugs and can deal with changes in dosage.
Lowering the dose of Zoloft can also induce negative side effects if done too quickly, including anxiety
I urge you to bring her to a psychiatrist because of the complicated nature of her interaction with these drugs. She needs careful monitoring to stabilize her emotions and behavior.
Elliott Sewell, LPCC, NCC, CCMHC