On the 27th my pharmacy told me that tranxene (Clorazepate Dipotassium) that i had been taking for the last five years quit making this drug but Mylan Pharmaceuticals makes it also. On the 27th I got it thinking it was the same. I feel like I am going through withdrawals. I ended up even having to go to the er. I STRONGLY BELIEVE THIS IS NOT THE SAME MED AS I KNOW MY BODY! Does anyone know of anyone else that are having problems with this drug made by this company?? I RATE THE OLDER DRUG A FIVE THE NEW ONE THAT IS SUPPOSE TO BE THE SAME 0!!!!!!!!!!! I have had harsh drug withdrawals. WITHDRAWALS LIKE WORSE PANIC ATTACKS EVER, SWEATING, SHAKING MY EMOTIONS INSIDE MY HEART HURT...SUICIDAL?? MAYBE IF I DIDN'T HAVE GOOD SUPPORT AROUND ME. My doctor has switched me to xanax which is working so far. You can track to the day when all this started happening when i started the "fake". There are more side effects but don't want to overload anyone
Person's Gender: Female
Person's Age: 31
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I understand but we do need to find an expert in head medications. I am sure it is not an easy task. But i really hope we can find an answer soon
Thank you for your continued patience;-)
Atleast i am getting some help through my pharmacist, drug co called and my internal med doctor. The drug company is going to do some testing on the pills to see what is wrong with them. I have not built up a tolerance. One doctor said he is not experienced enough in head meds but thinks i may all of a sudden built up a tolerance but even when I take more it didn't work. Since the attacks i have had klonopin worked for the first panic attack, at the er they gave me ativan and then internal medicine gave me xanax and it seems to help more than the others. Please try to help. I just know it is withdrawals. I haven't been able to go to work all week and i cannot lose my job.
Atleast i am getting some help through my pharmacist, drug co called and my internal med doctor. The drug company is going to do some testing on the pills to see what is wrong with them. I have not built up a tolerance. One doctor said he is not experienced enough in head meds but thinks i may all of a sudden built up a tolerance but even when I take more it didn't work. Since the attacks i have had klonopin worked for the first panic attack, at the er they gave me ativan and then internal medicine gave me xanax and it seems to help more than the others. Please try to help. I just know it is withdrawals. I haven't been able to go to work all week and i cannot lose my job. I couldn't help to not breakdown today when i tried to see a psychiatrist they told me i need more intense therapy and he has schizos that he deals with!!!!!! I need answers.
Thank you for your continued patience;-)
no problem. just let me know when you can find someone qualified enough....surely there is someone out there, right?
Hello, My names Tony I'm a Specialist Mental Health Nurse.I have read through your questions and could contribute some of your symptoms to a Benzodiazepine withdrawal as they could all be attributed to anxiety, a common symptoms of Benzo withdrawal.It is highly unlikely though that you would experience a Benzo withdrawal when taking the same drug, in the same dosage only produced by a different manufacturer. To produce a drug under a generic name a manufacturer must ensure that the drug they are producing has the same active ingredients as the brand name product, in the same dosage form at the same dosage / concentration and in the same route of administration...They are also compared to the brand product for bioequivelance ensuring they would act the same in the body.They can however use different inactive ingredients and preservatives which its possible your body had a reaction to. are believed to work by binding to the GABA receptors in the brain, for the purpose you are using the Xanax (Alprazolam) will probably work just as effectively but has a much shorter half life so doesnt work for as long.The half life of a drug is the time it takes your body to remove exactly one half of it from your system.Clorazepate half life is 36-200 hrsAlprazolam is 6-12 hrsyou may be better taking something like Clonzaepam with has a half life of 18-50hrsor Diazepam which is 20-200hrs or Medazepam which is 36-200hrs.Please speak with your prescriber about these alternatives.I hope this answers your question.However the generic brand products anxiety, apprehension, tremor, insomnia, nausea, and vomiting upon cessation of benzodiazepine use. Withdrawal from benzodiazepines should be gradual as abrupt withdrawal from high doses of benzodiazepines may cause confusion, toxic psychosis, convulsions, or a condition resembling delirium tremens. Abrupt withdrawal from lower doses may cause depression, nervousness, rebound insomnia, irritability, sweating, and diarrhoea.
UK trained Mental Health Nurse. Experience in acute care, Rehabilitation and Drug & alcohol treatments.
while going through the withdrawals i did take valium (Diazepam) and klonopin (Clonzaepam)and they didn't help much at all. Unfortunately the doctor said only take 2 xanax a day but i am finding 3 is keeping me more steady.
while going through the withdrawals i did take valium (Diazepam) and klonopin (Clonzaepam)and they didn't help much at all. Unfortunately the doctor said only take 2 xanax a day but i am finding 3 is keeping me more steady. also i am still taking klonopin to sleep...i mean it is midnight here
The reason you would have continued to withdraw with Diazepam and Clonazepam is that they both have a long half life and take it takes a few days for you to feel the full effect.Because they both have a long half life when taking either of them over a few days you get a kind of overlap leading to higher levels in your blood, a cumulative effect.You would be better moving onto something like clonazepam now you are not having withdrawals.This would mean you continuing to take the Alprazolam for 2 - 3 days whilst the Clonazepam was titrated up to whichever dose you require before stopping the Alprazolam.You should also probably be looking for a referal to an outpatient psychiatrist or psychologist so you can develop coping mechanisms for your anxiety which do not use medication as a backbone. Learning to cope with your anxiety without medications would be a much more sustainable option long term as you will continue to develop tolerance to the Benzodiazepines and be more at risk of long term side effects such as memory loss and organ stress as well as a more difficult withdrawal in the future.Also in regards XXXXX XXXXX for sleep, you would be much better with something like Temazepam which is indicated for insomnia.better still use a non benzo drug as this will also increase your tolerance to benzos decreasing the therapeutic effects of whichever drug you use for anxiety in the daytime.Zopiclone and Zolpidem are both effective insomnia drugs and non Benzo based,I hope this answers your questions :)Tony
Thank you. I am glad i am not crazy but i think it would be a bad mistake to discontinue benzos. I have been through a ton of therapy and realized some ppl just need it.
Yes do not simply discontinue the benzos unless advised by your prescriber but setting a medium to long term goal for you to use a small dosage or just as required in stress inducing situations would be something you could work towards.I hope you enjoy the rest of you day :)And feel free to message me again if you have any further concerns.Tony
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its 1:00 a.m. here i have been waiting for a response all day lol
Im very sorry, Im in Australia so there is the time difference :)Hope you manage to sleep ok :)Tony
Thanks. I will now. I appreciate your help Tony. Too bad your not in the USA if you go to New Zealand wave to Lucy Lawless for me lol. Have a good day. i will try to sleep now
Thanks. I will now. I appreciate your help Tony. Too bad your not in the USA if you go to New Zealand wave to Lucy Lawless for me lol. Have a good day. i will try to sleep nowOne last thing is caffeine bad with the benzos? i read online you should quit all caffeine while going through this.
Tony, while comparing the inactive ingredients they appear to be the same. The old ones and the new ones!!?? Opinion?
Caffeine can cause hypertension and symptoms of anxiety so yes should be avoided in large quantities but would not significantly effect benzos.In regards XX XXX ingredients, probably not the culprit.But there are 101 different things that could have caused your symptoms in the first place, I dont believe it was the change of brand due to reasons already listed.Its difficult to give any further guidance, I was just suggesting some possiblities.Do enquire about a move onto a longer acting benzo for long term use though.Thank you, Tony
Tony, I told my pharmacist about what his opinion was and here it is:Laura something just doesn't add up. The active drug is still the the active drug whether it be Mylan or Ranbaxy or whoever so either your body has changed which seems unlikely that quickly or it is an inactive ingredient that you had a reaction to. This also seems rare, but clearly something did happen, just don't know how to fully explain it. Not sure anyone can...
Hey thanks for your update :)Yes, very similar response to that which I had given, highly unlikely to be the result of a change of manufacturer because of how stringent the governments are in controlling drug production and the use of generic names.As you had stated the inactive ingredients were the same and a reaction is unlikely, I am glad however you presented at the ED for a full check over and was medically cleared.Also that you are now stable on your medications with no current side effects / withdrawal effects.Do consider the change we discussed earlier though, also antidepressents are good for anxiety and may be a way out of using the benzos long term. SSRI's would be a first line and SNRI's would be a second line of treatment.maybe a way of reducing your benzo dosages if not a way to replace them. :)Thanks again,Tony