Have Mental Health Questions? Ask a Psychiatrist Online
Anxiety and depression are in most cases caused by neurochemistry (unless you are making a connection b/w the events - divorce/laid off) after which you notice a worsening of your symptoms. The latter would be seen as psychological and emotional triggers (even suppressed ones) affecting your well being. Something else to look into would be a sleep study to rule out nocturnal seizures, sleep conditions i.e. REM sleep disorder and sleep apnea as these can cause neurological changes and affect your mood/anxiety level during the day. Many antidepressants suppress one's REM sleep cycle and you're on multiple different ones.
**Psychotropic meds that work on the norepinephrine levels can also cause increase in the dopamine levels which relates to the fight or flight response. In that case, you may perceive an increase in anxiety/irritability/agitation and difficulties sleeping.
You've mentioned that your anxiety responds to a higher dosage of the medication and a question for your prescribing psychiatrist would be if you've reached a threshold where the medication at the current dosages is not effective. You may want to speak with your MD about what your base line is according to him/her.
In addition to medication and talk therapy, other therapeutic modalities to look into would be biofeedback/neurofeedback and hypnotherapy.