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I have extensively searched for drug interactions between vyvanse and tenex (guanfacine) and found no negative interactions when using both. This was backed up by drugs.com which said that from their cross-referencing of their database there were no interactions, although there could be some in any drug combinations (which is their disclaimer, and mine).
Tenex is an antiadrenergic agent, which acts centrally and is used to treat High Blood Pressure, especially with those with ADHD.
Vyvanse is a central nervous system stimulant, used to treat ADHD, Asperger Syndrome, Chronic Fatigue Syndrome, Narcolepsy, and Oppositional Defiant Disorder.
Vyvanse can have negative interactions with
- alpha blockers (e.g., prazosin)
- antipsychotics (e.g., chlorpromazine, haloperidol)
- certain antidepressants (e.g., tricyclics such as nortriptyline/imipramine, SSRIs such as fluoxetine/paroxetine, duloxetine, venlafaxine)
- certain anti-seizure drugs (ethosuximide, phenytoin, phenobarbital)
- certain pain medications (meperidine, propoxyphene)
- certain street drugs (e.g., LSD, MDMA/"ecstasy")
- medication for high blood pressure (e.g., beta blockers such as atenolol/metoprolol, clonidine, guanethidine, methyldopa)
- medications that affect the acid level of the urine (e.g., sodium bicarbonate, acetazolamide)
- other stimulants (e.g., methylphenidate)
- sedatives (e.g., lorazepam, certain antihistamines such as diphenhydramine)
- veratrum alkaloids (e.g., cevadine, veratridine)
But NOT with Tenex.
I hope this has been helpful.
Elliott Sewell, LPCC, NCC, CCMHC