Thanks for your reply.
The normal daily dose of Wellbutrin is from 225 -450 mg per day. 450 mg is the maximum dose and you are currently on the maximum dose but still not responding fully so in my view, adding another antidepressant to Wellbutrin could be a good idea.
mainly acts on two neurotransmitter namely dopamine and norepinephrine and adding another antidepressant which acts on a different neurotransmitter serotonin will augment the antidepressant effect of this medicine.
Now, SSRI antidepressants
are those antidepressant which mainly act on serotonin neurotransmitter so adding a SSRI antidepressant to Wellbutrin should be useful in your case.
Fluoxetine (Prozac) is an SSRI antidepressant which does not cause weight gain, in fact in some patients, it may cause lack of appetite and hence weight loss. Sertraline (Zoloft) and Escitalopram (Lexapro) are another two SSRI antidepressants which also does not cause weight gain.
Wellbutrin it self does not cause weight gain so a combination of Wellbutrin along with Prozac should not cause weight gain.
Therefore to summarize, adding a SSRI antidepressant such as Prozac to Wellbutrin will augment the antidepressant effect of Wellbutrin. Since Prozac is also an effective antianxiety medicine it will also help in controlling anxiety
symptoms if you have any.
Since both Wellbutrin and Prozac are weight neutral therefore there should be no problem related to weight gain also.
I hope this helps.
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