Hi, I'd like to help you with your question.
If you have been on these medications for more than two years, the effectiveness may no longer be there. After two years, SSRI's do not work. So you may either need to change the dosage or change your medication.
Considering that you have tried many medications and combinations over the years and have not found relief, you may want to consider other options. You mentioned being in therapy twice a month, but seeing a therapist weekly would be much more effective. Also, do you feel that your therapist is helping you? Finding a therapist is like finding your family doctor, it may take a few tries to find someone who is compatible and who can help. To find a therapist, talk to your doctor about a referral. Or you can search on line at http://therapists.psychologytoday.com/rms/. This link helps you find a therapist and also provides a brief history of what the therapist does. Any Master's level or Ph.D level therapist can help you.
Also, self help is a good option. Many people find relief through answers they can find in books and on line. Here are some links to help you get started:
http://helpguide.org/mental/depression_signs_types_diagnosis_treatment.htm- this also has a helpful section on medications, types and options.
The Depression Cure: The 6-Step Program to Beat Depression without Drugs by Stephen S. Ilardi
Undoing Depression: What Therapy Doesn't Teach You and Medication Can't Give You by Richard O'Connor
The Cognitive Behavioral Workbook for Depression: A Step-by-step Program (Workbook) by William J. Knaus and Albert Ellis
You can find these books on Amazon.com or your local library may have them for you.
You may also want to consider support groups. Having others who share your experiences and have found other solutions can help tremendously in your recovery. Here are some links to help:
I hope this has helped you,Kate
I haven't heard from you. Did you have more questions or want clarification?