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Savella is only for the fibromyalgia. You may want to stop it but your anxiety and depression being uncontrolled may be more the cause of the problems. Savella cannot be quit cold turkey without adverse effects. If you want to quit, you need to talk to MD. You may also want to try a less stimulating antidepressant for depression and anxiety (maybe lexapro, celexa). All of them may temporarily cause increase anxiety/depression (for a couple weeks). Savella can also exacerbate depression. ER is correct about heart rate, even though it may feel uncomfortable. Given the complexity of this sensitivity to medications, I am reluctant to advise anything specific other than to note your treatment does seem ineffective. I would see a psychiatrist to deal with the complete picture.