It sounds like you are feeling quite miserable and like things are spinning out of your control. The things you are describing are fixable problems. Do not give up hope. You deserve to feel better. I think it would be helpful to prioritize things. First of all, your drinking wine every night has to be addressed. You need to stop. Alcohol is a depressant and only adding to your problems and low mood. I am not saying it is the primary problem, but you are using it as a fix and it is not working. In fact it is making things worse. If you find it difficult to stop, seek out and attend AA meetings. The only requirement for attendance is a desire to stop drinking, you do not have to be an alcoholic. The meetings will give you support and tools to not drink. You can find meetings at www.aa.org. Then you can address the other issues you have. I strongly recommend that you get into counseling/therapy to work on your low mood, eating issues and low self-esteem. The last thing you will want to work on is your relationships with your daughters. Some of the conflict with them will resolve as you work on the first two things - not drinking and yourself. Do not delay, make an appointment with a counselor today and make the crucial first step to feeling better. Your life will improve and your relationships with your daughters will improve. Good luck to all of you, let me know if you have further questions.