Safe is a relative term. I have had many patients on 3 antidepressants and even more on 2. The main risk of combining these is called serotonin syndrome (see this link: http://www.mayoclinic.com/health/serotonin-syndrome/DS00860).
Keep in mind that there is not enough long term research proving long term safety with antidepressants. There is even less research that can prove long term safety when combining antidepressants. The problem is this type of research is hard to do.
The botXXXXX XXXXXne is this: any treatment has benefits and risks...if taking 3 antidepressants seems to be helping you...and you are having minimal side effects, it may be worth continuing these meds. Weigh the pros & the cons. Just keep an eye out for serotonin syndrome. I hope this helps. Let me know if you need more info.
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the link below explains it well...
Serotonin syndrome occurs when you take medications that cause high levels of the chemical serotonin to accumulate in your body. It can occur when you increase the dose of such a drug or add a new drug to the ones you take already. Certain illicit drugs and dietary supplements also can cause serotonin syndrome.
Serotonin is a chemical produced by your body and is needed for your nerve cells and brain to function. But too much serotonin causes problems. Symptoms of serotonin syndrome range from shivering and diarrhea to severe symptoms such as muscle rigidity, fever and seizures. Severe serotonin syndrome can be fatal if it isn't treated. Serotonin syndrome usually goes away within a day of stopping the medications causing symptoms and taking drugs that block serotonin, if needed.
Serotonin syndrome symptoms typically occur within several hours of taking a new drug or increasing the dose of a drug you're already taking. Signs and symptoms include:
Severe serotonin syndrome can be life-threatening. Signs and symptoms include:
When to see a doctorIf you suspect you might have serotonin syndrome after starting a new drug or increasing the dose of a drug you're already taking, call your doctor right away or go to the emergency room. If you have severe or rapidly worsening symptoms, seek emergency treatment immediately.