I think she may have some serious problems which are impossible to to diagnose via the net. I think if you try to protect your friend at this point, you will probably loose him as he will chose her over you in a conflict. So I would avoid getting in the middle with the information that you have. I would a single time tell him that you have concerns for his well being with his wife and you are available to t talk to him should he chose, but after this one initial offer I would drop it. You are in a no win situation unless your friend asks for advice. There are times that there is nothing you can do and this appears to be one of them. Be there should he need you, but don't intercede.Best wishes.
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