Sorry to have lost my patience, but thought I had found an explanation that could relate to me. It could be an argument for dropping Marplan with all it´s sidereactions. I enclose two articles related to stress and depression.
From MedScape Today: http://www.medscape.com/viewarticle/581740
Stress During Childhood Affects Psychopathology in Psychiatric Patients
Increased early life stress was confirmed for a larger sample of psychiatric inpatients treated for severe mental disorders. Present results support the hypotheses of stress-sensitive periods during development and show that a 'dose'-effect, a relationship between the amount of stressful experiences and severity of distress, is not restricted to traumatic experiences and to PTSD. Results also suggest that relationships between early life stress and psychopathology vary between disorders, which may result from an interaction of early life stress with other vulnerability factors.
Results support the hypothesis of stress-sensitive periods during development, which may interact with genetic and other vulnerability factors in their influence on the progress of psychiatric disorders. A 'dose' effect of stress load on the severity of psychopathology is not restricted to the relationship between traumata and PTSD.
From the Danish hospital:
Stress is in the genes
New research shows that the number of serotonin receptors in certain areas of the brain is genetically determined and it affect your ability to handle stress. Its the Neurobiological Clinic who are the first in the world to have found out via a twin study.
Imagine your life as a landscape where your path is substantially predetermined, because the mountains, rivers and roads are already present at birth. The landscape may change due to external influence, and you can even choose to ascend difficult mountains, but mostly you will follow the already made roads tells physician in the Neurological Clinic Lars Pinborg. A part of the landscape, as Lars Pinborg and the research group at the Neuro-Biological Research have found out, are outlined in advance, depends on how many receptors you have in the brain serotonin system. The system is one of the important signaling in the brain and include of receptors that receive signals from such body or other parts of the brain. Scientists know that the system has implications for psychiatry-made diseases as depression and schizophrenia, and drugs designed to treat these diseases, therefore, are directed to this signaling.
Personality Tests and scans
In a series of research focusing on patients with psychiatric and neurological suffering look, we have a total control of approx. 100 ra-persons to compare with patients, says Lars Pinborg. The control group were both scanned and personality testing to learn as much as possible about the personality and brain structure and function. Here, the researchers noted that the number of receptors among healthy varied considerably from person to person. The question, Lars Pinborg and co. asked was whether variation in the serotonin system could have an impact on personality? By comparing the scans and personality tests, they found out that people with many serotoninreceptoror in the front part of the brain, specifically the frontolimbiske areas have a reduced ability to handle stress. It is a characteristic that researchers know is linked to the development of depression later in life.
Inheritance or environment?
The next question is whether the number of receptors as a marker for the reduced ability to handle stress, altered in the course of their lives - perhaps because the 16-year losing a parent - or whether it is something you really in baggage through the genes. In short, due to the inheritance or environment? One way to investigate it is by twin studies, comparing identical twins who share the same genes, and twoegged twins, who have 50% of genes in common. If we could show that the oneegged twins were very similar compared to the twoegged twins, then we could conclude that genes are much more important than the environment, "says Lars Pinborg.
As the first in the world have research group with Lars Pinborg by a twin study demonstrated that the number of these serotonin receptors in the brain is largely genetically determined, because they could see that they are identical twins PET scans of serotonin receptors were much more similar than the tvwoeggeds. If we compare it with the number of receptors in a specific area in the brain which are important for a personality that we know predisposing to the development of stress and subsequent depression, it is reasonable to conclude that the personality is in the genes and the links via the serotonin system, "says Lars Pinborg.
Predict and influence
Prospects in the new field of research is to predict, but also to influence. We will of course like to be able to predict disease, but it is also interesting to know where in the brain and how disease occurs and try to affect the area and the relevant biochemical process, thus targeting therapy, said department physician. But if the aspects of personality and the risc to suffer from depression is no longer arbitrary, the question is surely how free we are as people? I think that it is how we at birth or very early in life has had our outroads. Our lives are not just ahead of us as a blank billboard, as is familiar from Aristotle, but the path of several that we choose is still up to us and therefore we are also responsible for our choices. But just as depression is concerned, it is good to ease the burden of responsibility from the patient's shoulders, close Lars Pinborg.
Lars is registred here with more articles: http://www.biomedexperts.com/Portal.aspx .