Thanks for the reply.
Well, your doctor was right in saying that seroquel ( quetiapine, an atypical anti psychotic ) causes weight gain , as one of the side effects of atypical anti psychotics is weight gain, also he rightly pointed out that serzone (nefazodone) causes liver damage on prolonged use ,and for the same reason, it has been withdrawn in some countries.
And , one thing stands out for an observation , and that is , you suffer from panic attacks , which is a type of anxiety disorder and so ideally along with the anti depressants , which act as good anti anxiety agents , one should give adequate dose of anti anxiety drugs , however , in your case you have been placed on xanax 0.5 mg three times a day , which i feel is a substandard dose , more so , i feel you should be placed on a better anti anxiety drug. Also, you have been over loaded with anti depressants -- paxil ( paroxetine, ssri anti depressant ) and effexor ( venlafaxine , an snri anti depressant) and that too a number of doses, which i feel is creating resistance in your body against these drugs , as a result their effectivity has decreased.
So, now , i shall mention a treatment regime ,which you should discuss with your doctor and get started on it, and i am sure you will get relieved of your panic symptoms, but i will also endorse the view of your doctor , to stop the use of serzone , as it has harmful effects on the liver, which may create a bigger problem for us in the future.
So , following drugs you should be placed on--
1) Anti depressants--- Well, you should stop seroquel and serzone , as adviced by the doctor of yours for reasons discussed above, do not worry i have alternative drugs to replace them , which will make you feel as better as ever. So, i suggest you increase the dose of Paxil to 20 mg , to be taken once a day only, and that too in the morning. Stop Effexor as you are not tolerating the drug well, although it is one of the best drugs, but if it is creating more problems than solving them, it is better to discontinue it , but make sure you taper the dose of effexor over 1-2 weeks and then stop it, as abuptly stopping effexor would cause discontinuation syndrome ( withdrawl symptoms) , so you need to reduce 37.5 mg three times a day to two times a day initially , keep it that way for 5 days and then furher reduce to effexor 37.5 mg once a day , keep it maintained for another 5 days and then stop it. Also in addtion to paxil 20 mg you should add Cymbalta 40 mg , once a daily dose taken at night .
2) Anti anxiety drugs --- Well, instead of xanax you should be started on Clonazepam 1 mg , to be taken two times a day after meals.
3) Psychotherapy --- In additon to the medications , you need to take a short course of psychotherapy ( counseling in lay terms ) , offered by a clinical psychologist, and the best type of psychotherapy for panic disorder is Cognitive Behavioural therapy ( CBT) , WHICH is as effective as drugs and in combination with them will definitely ork wonders for treating your longstanding panic disorder.
So, to summarize ,you need to be started on Paxil 20 mg , once a day in morning, Cymbalta (duloxetine) at night, clonazepam two times a day and CBT and KINDLY DISCUSS THE DRUGS, THEIR DOSGAGES AND TIME OF INTAKE WITH YOUR DOCTOR .
I WISH YOU RAPID RECOVERY TO THE BEST OF HEALTH .
I hope my answer serves your query according to your satisfaction.