It is much safer than placebo 50mg..
The most adverse reactions are..
, hyperhidrosis, constipation, and decreased appetite. But there is no hard and fast rule that these symptoms should appear in patients that use this drug..
The only thing is that, after begining the medication, you keep in regular touch with your doctor and give him the feedback on how the drug use is panning out.. If you report any adverse effects, he can adjust therapeutic regimen..
Also, don't research too much into the side-effects of Pristiq, It can bring imaginary side effects..
My websearch says that, it is a new, improved drug and is relatively safe..
So, have confidence in your doctor, start using the medication, while keeping in touch with your doctor, atleast during the initial phases of your medication..
I hope this helps..