Yes, Zolpidem & Benadryl can be taken together safely and these two drugs are not expected to produce any serious or major drug interactions. There are no known contraindications to use these 2 drugs together.
There are patients have used these 2 drugs together and clinical experience shows there are no major or serious drug interactions known to occur when these 2 drugs are used together.
Issues like increased sedation may occur when these 2 drugs are combined so precaution is recommended related to driving or related to activities that may require focus, attention, balance & coordination etc, but as far as serious adverse reactions are concerned there are no such concerns with this kind of drug combination. Also because of the possibility of excessive sedation - in the beginning you may combine relatively smaller doses of these meds and then optimize the dose depending upon how you tolerate this combination.
Once again I reassure you Zolpidem & Benadryl can be used together safely as discussed above.
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