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Family Physician
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Experience:  Emergency Medicine and Family Practice for over 26 years
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What is the fat producing ingredient in Invega

Customer Question

What is the fat producing ingredient in Invega (Paliperidone) and is there a counter medication that would stop fat growth while taking invega
JA: What medications do you take daily? Are you allergic to any medications?
Customer: Focalin 10mg,Invega 3mg,Paxil 30mg, and Trazadone 100mg
JA: Anything else in your medical history you think the doctor should know?
Customer: no, other than when off of Invega my weight is 40 to 50 pounds less
Submitted: 2 months ago.
Category: Medical
Expert:  Dr. Vikas replied 2 months ago.

Hello,

As such there is no particular ingrediant and Paliperidone itself can cause weight gain in some patient

In fact, as you must be knowing that Paliperidone is an atypical antipsychotic and nearly all Antipsychotics (AP) specially Atypical Antipsychotics can cause weight gain in patients taking them.

" Several factors explain weight gain due to AP and the impact of duration of AP use on bodyweight. AP medication induces changes in appetite and food intake, most likely because of interaction with serotonergic [32], histaminergic [33] and dopaminergic [34] neurotransmitter systems inducing increase in appetite and food intake. Therefore, the effects on weight and Body Mass Index (BMI) likely will progress with time. Duration of AP use thus is thought to constitute an important factor contributing to weight gain "

Source : Almost All Antipsychotics Result in Weight Gain: A Meta-Analysis

Recommending an article below regarding how to deal with the weight gain due to invega.

Suggestions for Dealing With Invega and Weight Gain

Topiramate is one such medicine which is being used currently for controlling Antipsychotic induced weight gain.

Topiramate: Antipsychotic-Induced Weight Gain

If you are very much concerned with weight gain due to Invega, you can also discuss with your doctor about switching over to certain weight neutral antipsychotics like Aripiprazole, Ziprasidone and Amisulpride as a replacement of Invega. These 3 antipsychotics usually does not cause weight gain.

Would like to know your views regarding my suggestions. Please feel free to ask if you have any other query