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Hello this is Dr. Stan and I will assist you with your question today. I am U.S. trained,
Board Certified and I have 40 years of patient experience. I am happy to help you. I'm sorry your wife is having difficulty with her thought process.
What medication does she take?
What was her last TSH test result number?
I will assume that her thyroid function is controlled with medication and her iron levels are also back to normal. Since her MRI and CT scans are normal, then hydrocephalus and tumor have been eliminated as a cause. Since she has been non-responsive to multiple antidepressants, the next step would be to consider ECT to bring her out of her depressive state. Discuss this with her Psychiatrist.
I am available to answer any additional questions you may have. Thank you for allowing me to provide assistance. I hope your medical problem(s) are resolved soon and you feel better. If you find the information I provided helpful, so I am compensated for my service, please rate me with 5-Stars. Thank you