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Skin graft failure can result from insufficient vascularity of the recipient site, hematoma, seroma, infection, excessive tension, or mechanical shearing forces. Proper preparation of the wound bed, meticulous hemostasis, careful inset of the graft, and proper dressing along with immobilization during the healing period can help avoid most of these complications. However, it is some inevitable.
Comorbidities including diabetes, smoking, protein or vitamin deficiencies can affect vascularity and wound healing. In addition, medications such as steroids, immunosuppressive medications, and anticoagulants can interfere with wound healing.