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Plavix and Aspirin inhibit the blood clotting and do not influence vigilance. His tiredness may result from the efforts to regain back his life. After a stroke normal living is much more straining than before.Nevertheless he should be checked for anaemia, heart failure and depression.
I hope I helped you with the answer you asked for: His tiredness is not due to his medication.
And please take my advice to check depression seriously
Thank you for ratinf my help on a sunday positively.