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One lortab pill will not likely cause any problem. Nusolv is suboxone like composition containing opiate partial antagonist to deter abuse of other opiates. However, the serious reactions are observed with large dose of opiates not with one or two pills usually. Still, it is better to avoid other types of opiates while on nusolv.Best wishes,It was my pleasure to help you today.If I have answered all your questions, Please rate my response Excellent (click on the 5th star).Please bookmark my profile for fast, reliable and authentic answers!This is the link to my profile:http://www.justanswer.com/medical/expert-mysticdoc/