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I am a Family Medicine doctor, board certified with active licenses and certification in Internal Medicine, Pediatrics, Obstetrics and Gynecology, as well as Integrative Medicine & Naturopathy, with advanced training in Neurology, Cardiovascular Medicine, Gastroenterology, Endocrinology, and Psychiatry. I am also well-trained in Functional Medicine. Perhaps most importantly, I consider myself a patient listener.
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The answer mostly depends on your sensitivity to these medications. Both are psychoactive, and both can cause cognitive, cardiac, and respiratory slowing. If they are medications you've used before, or regularly, they are likely to be safe. If you have not used them before, you may feel more tired or more slow, generally, than you would want.
How old are you, do you take any other medications? Why are you taking these?
I see. Hydrocodone is not a good medication for muscle strain. Both ativan and hydrocodone are very addictive, and cause more than 75% of the national opiate addictions. That being said... if you can avoid taking the hydrocodone , you are probably better off. There are much better alternatives.
To your specific question, it is "safe" from a pharmacodynamic perspective (the way the drugs act in your system), but none of these medications are considered "safe" in general. Provided you are being closely monitored and supported, and you're not operating machinery (including a car), they are safe.
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