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skin fungal infections often like to grow in dark, warm, moist environements and often can take months to weeks to clear
the doxy and nystatin helping sounds like it is most likely a skin fungal infection.
make sure you use the nystatin powder 4 times a day and use it for 1 week after the redness goes away
keep the scrotum and pelvic area as dry as possible
you may need to use baby powder once or twice daily in the future to keep the skin dry there to prevent return of skin fungal infections on the scrotum.