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There is a good chance that this drug will be detected in a screening test performed 53 days after a single use. The Vyvanse is converted into dextroamphetamine, and the usual period of detection of dextroamphetamine is up to 3 days after a single use and can occasionally bve detected up to 4 days after a single use.
As with all drugs, the rate of metabolism varies between individuals, even of the same height and weight, and there are some people in whom it will only be detected for 2 days. So, it is possible that the drug will not be detected. But, there is a good chance that it could be detected at 53 hours after a single use.
Sweating will not significantly alter the period of detection, but drinking a good amount of fluid can help somewhat by diluting the urine and decreasing the concentration of the drug metabolites in the urine. If you drank so much fluid that you used the restroom 15-25 times during this period, then you were drinking sufficient fluid to put yourself in the best situation to pass the test.
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