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khagihara
khagihara, Doctor
Category: Medical
Satisfied Customers: 6585
Experience:  Trained in the multiple medical fields for many years.
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What reasons besides cushing disease /!syndrome or chrousus

Customer Question

What reasons besides cushing disease /!syndrome or chrousus syndrome can give you ufc 24h larger than 500? ( max 60)
Submitted: 4 months ago.
Category: Medical
Expert:  khagihara replied 4 months ago.

I am wondering what ufc is.

Customer: replied 4 months ago.
Urine free cortisol
Expert:  khagihara replied 4 months ago.

Can you tell me more about your situation?

Customer: replied 4 months ago.
I've got ufc24h larger than 500 ( 7 tests , max 50). Cushing disease as been ruled out.
Expert:  khagihara replied 4 months ago.

What tests did you have besides ufc?

Customer: replied 4 months ago.
Everything else is ok.
Blood cortisol is a little high, didn't supress dexamethasone , maintain circadian rythm on salivary controls
Expert:  khagihara replied 4 months ago.

Low dexamethasone or high dexamethasone? What are your symptoms?

Customer: replied 4 months ago.
Failed to supress on low 3 times. Supressed on high. ACTH normal. MRI on pituitary clean. Only symptom is muscle wasting and gaining fat ( lost 12 kgs on 4 months)
Customer: replied 4 months ago.
No diabetes, no hypertension, no strias, no Cushing stigmata. Cushing has been discard
Expert:  khagihara replied 4 months ago.

ufc was measured twice?

Customer: replied 4 months ago.
Seven
Expert:  khagihara replied 4 months ago.

Are you a male or a female? How tall are you? How much do you weigh? Any weight change? When did it start? Is it getting worse? Any other symptoms? Are you aware of anything which might have triggered it? Any medical problems? Any surgeries? Any medications including over-the-counter pills and herbs? Any family medical history?

Customer: replied 4 months ago.
Male, 37, 188 cm, 88 kgs ( was 100 in March). Progressive mucscle loss and fat gain on belly and chest.
Labs ok but ufc24 extremely high
Expert:  khagihara replied 4 months ago.

Did you have inferior petrosal sinus sampling?

Customer: replied 4 months ago.
No. IPSS is done when Cushing is confirmed. Cushing was ruled by doctors for lack of symptoms
Expert:  khagihara replied 4 months ago.

The diagnosis of CS is established when at least two different first-line tests are unequivocally abnormal. The first-line tests are late-night salivary cortisol (two measurements), 24-hour urinary free cortisol (UFC) excretion (two measurements), or the overnight 1 mg dexamethasone suppression test (DST). You have abnormal results in UFC and DST. You have CS. And since high dose DST suppressed cortisol and MRI is negative, you should have IPSS.

Customer: replied 4 months ago.
Cushing was ruled out by hospital
Customer: replied 4 months ago.
I was Ingressed 5 days followed the hospital protocol and Cushing was ruled out. What other conditions may lead to high urine 24 hours ?
Expert:  khagihara replied 4 months ago.

It is diagnosis criteria. You have CS. You need to have IPSS.

Customer: replied 4 months ago.
IPSS is done where cushings is diagnosed to tell its a pituary or ectopic. Cushing as been ruled out. Are there known cases of healthy individuals that show high cortisol, and in fact have an healthy cortisol (lab error, urine specificity ) ?
Customer: replied 4 months ago.
I've lost 4'cm . Is it related to cortisol?
Customer: replied 4 months ago.
What other reasons besides cushings can give you very high cortisol values ... 7 tests over 500 ( Max 60)?
Customer: replied 4 months ago.
Can it be cronical over stress with adrenal stress ?
Customer: replied 3 months ago.
Case solved. I dont have Cushing. Cortisol Was high from whey protein