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Loperamide is a pregnancy category B drug which means it may be acceptable as either the human studies have not done or if done their is no risk in humans although in animal studies it shown to have some harmful effect.
Now next thing is that if your wife has diarrhea you need to see the doctor as it might be due to infection and an antibiotic might be required to treat it. Anti-diarrheal are generally not advisable in acute diarrhea as they may result in retention of toxins and thus a more serious infection.
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