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Hi Dr Stan here to help. It depends on the cause. HydroCortisone 1% cream may be effective, but you should be evaluated to determine why you have the itching. Some causes are pinworms, hemorrhoid, diabetes, skin conditions and infection. You need to be evaluated, so go to Urgent Care. I hope this is helpful and I am here to answer any additional questions you may have. Please provide a positive rating of 3-5 stars for my response.