This is Dr. David
I am sorry you are having symptoms of weight gain, hair loss and fatigue
at your age of 49, you most likely are going through early menopause and decline of your estrogen levels which can cause weight gain, hair loss, fatigue, irregular periods, hot flashes
it may not be your thyroid hormone levels causing these symptoms.
you should talk to your GP doctor about options for hormone replacement therapy if you have gone through menopause or are going through menopause.
you may benefit from a bit of estrogen therapy or going on birth control pills to help bring up your estrogen levels which could help your symptoms.
regular exercise could also help you loose weight and have more energy and sleep better as well.
improving your diet and eating healthier foods can help you loose weight and could give you more energy.
your doctor can also refer you to talk to a nutritionist to help improve your diet.
so you have several options which can help.
are you on a birth control pill currently?
have you tried to exercise regularly?