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This is Dr. David
there is no drug interaction between lithium and prednisone
prednisone is very good at bring down inflammation, but it can suppress your immune system
you want your immune system stronger to suppress your herpes outbreak
what you should be on is an anti-viral agent like acyclovir or valcyclovir pills and creams to suppress the herpes virus and make it dormant again
do you have oral or genital outbreak of herpes currently?
is it getting better or worse currently?
are you on an antiviral agent?