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Thank you for your question.
Isosorbide does cause a lot of headache in some people.
If it is causing tremendous headache like you mention, I would recommend that he should discuss stopping this medication with his doctor and/or changing it to something else like a beta blocker or a calcium channel blocker.
I think that just by stopping the medication the headache should go away.
Let me know if you have more questions.
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Thanks for this question
I noticed the other expect opted out.
Can you tell me what meds he is on?
Isosorbide could precipitate increased intracranial pressure (high pressure in the brain). You should take him to ER to have the pressure checked and get medications to decrease the pressure.