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I would recommend seeing an allergist and possibly seeing a hematologist if you want better opinions regarding your itching and mesenteric lymph nodes. They would be able to do their own set of bloodwork. But given the fact that your year was terrible, it's very common to manifest anxiety as itching. Hydroxyzine is a very good anti-itching medication but also great for anxiety. Which might be why it help to you. If these specialists clear you then maybe talking to someone like a psychiatrist about this might help too. There are many reasons for someone to have itching, like you said something autoimmune or malignancy versus anxiety or allergy. From what everything they did so far, it sounds like a very good work up has been done. I think overall you should be reassured.
Yes that can absolutely happen with taking antihistamines. When you come off of them, the histamines are no longer inhibited and thus the rebound effect. But the underlying cause is what needs to be addressed. Anxiety it obviously a large component of this after reading about the hives/itching going away when you are relaxed and after sleep in the am. But I would first see an allergist, then psychiatrist next. You need an alternative medication to treat the anxiety and see if the itching/hives subsides. Dry air can lead to dry itchy skin, that's possibly, but not hives. My thoughts in summary is that this is most likely anxiety provoked itching (pruritis) leading to increased blood histamine levels. This is actually not too uncommon. But reassure yourself it is unlikely anything serious such as cancer or autoimmune.
You would very likely have neurologic symptoms if the brain was involved. Also, blood work would unlikely be normal if you had leukemia or lymphoma. Medications such as SSRI medications, SNRI or medications like Gabapentin may offer help with anxiety and itching. If cancer was involved, yes meds like hydroxyzine could possibly help, but anxiety is such a large component here and you've had an extensive workup. I would still see an allergist and certainly psychiatry. They will offer more reassurance because I'm sure they see this (itching/anxiety) even more often than an general internist.
I hope this helps you. I really wouldn't worry about cancer right now. Just seems very unlikely after the tests/imaging that have been done.
You sound very attuned to your body. Just keep on the lookout for other problems you might be experiencing. Although I don't expect anything else to happen. But again please follow up with an allergist and a psychiatrist. We definitely need control of your anxiety. Please keep me updated. Take care.
Things such as weight loss, soaking nite sweats, fever, blood in stool. Those are the main ones.
Sounds like a very thorough workup. You should feel reassurance based on whats been done.
Certainly good to do some research on your own as well. CBTherapy is something a psychiatrist could do if they specialize in it.