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Hello from JustAnswer.
I am sorry that you mother is having so much difficulty.
Which topical medicine was prescribed by her Gynecologist?
I had asked for some further information and have not heard back.
When someone has a persistent or severe diaper rash, there are several possibilities to consider. The common diaper rash is a reaction to irritation from the chemical composition of the urine. Some people can have a more severe reaction, similar to an allergic reaction. It is also possible that there could be a secondary infection of the rash. The most common secondary infection is a fungal infection, but it is also possible that the infection could be bacterial.
I ask about what topical medicine was prescribed because that may give a clue of which of these possibilities was thought to be present.
The next step would vary according to the type of problem. A severe reaction may need oral steroids. A fungal infection would usually first be treated with a topical anti-fungal, but if this is what the Gynecologist has already tried, then it may be necessary to use an oral anti-fungal, such as fluconazole. A bacterial infection would usually be treated with an oral antibiotic.
If I can provide any additional information, please let me know.