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Basically this may be due to cellulitis which is a common and potentially serious bacterial skin infection. Cellulitis appears as a swollen, red area of skin that feels hot and tender and the skin on lower legs is most commonly affected. Left untreated, the spreading infection can rapidly turn life-threatening, therefore it is important to seek immediate medical attention if cellulitis symptoms occur.
Also swelling in one leg may be due to clot in the veins causing mild to moderate swelling. In this case there is also pain, warmth, redness, and tenderness in the leg.
Hence both of these conditions are serious and need immediate management. Therefore please go to an urgent care facility or the emergency room of a hospital for an examination to diagnose the exact cause and based on this the treatment may given which can antibiotics for the infection.