Hello from JustAnswer.
Yes, it would be OK for someone taking losartan, a B-complex vitamin, and omega-3 to take the SAM-e supplement. There are no known adverse interactions between the SAM-e and the losartan or either of these supplements.
If the depression is more severe and is causing significant stress, then the depression may affect how well the losartan is controlling the blood pressure. So the control of blood pressure may get worse, but it would be more of a concern from the condition, not the supplement. This would not cause any concern about the use of the SAM-e, but it would be a reason to consider other treatment for the depression if the SAM-e is not effective.
If I have answered all your questions, please rate my response Excellent (click on the 5th star).
However, if I can provide any further information, please let me know.
Please bookmark my profile for asking further questions!
This is the link to my profile: