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1. DIC 2. Activation of the coagulation cascade leads to the production of thrombi consisting of fibrin and platelets. Formation of thrombi in turn leads to consumption of endogenous coagulation factors, platelets, and anticoagulant factors (eg, protein S, protein C, antithrombin). Fibrinolysis is activated at sites of thrombus formation, with generation of fibrin degradation products (FDP) like D-dimers and consumption of fibrinogen that, when present in significant amounts, interfere with both fibrin clot formation and platelet aggregation.