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This is Dr. David
if you are feeling worse, I would see a doctor for a full physical exam and blood testing.
you could have a sinus infection causing strange smell.
you may not be sleeping as deeply with ambien at night time which can cause you to be more fatigued.
Vyvanse can cause jitteriness and anxiety and can cause aggitation as well as poor sleep.
are you feeling "bad" as in more fatigue during the day ?
you should see your doctor
and get your thyroid hormone levels checked.
hyperthyroidism can cause you to be more agitated.
have you had your thyroid hormone levels checked?