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Basically with the symptom of a depressed mood and also for the reduction of breast size complaint you need to consult your doctor as soon as possible. Treating the depression would be the first priority. Regarding breast size, the treatment would be cosmetic surgery. However a complete evaluation by a qualified cosmetic surgeon, including a complete breast health history, is advised before you consider surgery.
We cannot tell with certainty, since the breasts may or may not return to their previous size with weight gain. However the weight does have an influence on breast size, and with a regain of healthy weight the breast size is likely to increase.