I understand your concerns for your father.
He has undergone lot of stress from massive PE, also diabetes, high cholesterol.
He is on multiple medications as well.
These can take a toll on his health at some point.
Medication side effects, dehydration, electrolyte abnormalities are common causes.
Also hypothyroidism, adrenal gland insufficiency, testosterone deficiency can manifest as low in spirits.
Depression is the diagnosis of exclusion.
Heart failure is also possible with such PEs.
Hence, echocardiogram also is needed.
Iron deficiency anemia, vitamin B12 and folate deficiencies also should be checked.
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