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Dr. SH
Dr. SH, Board Certified Physician
Category: Medical
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Experience:  Doctor of Medicine
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How does hydrochlorothiazide lower blood pressure chemically

Customer Question

how does hydrochlorothiazide lower blood pressure chemically in your body
Submitted: 1 year ago.
Category: Medical
Expert:  Dr. SH replied 1 year ago.
Hi there.
Thank you for your question.
I will be helping you out with your queries.
Hydrochlorthiazide lower blood pressure by two mechanisms mainly:
1. Increasing sodium and water loss in the urine causing lower blood volume and thus lower blood pressure.
2. Dilation of arteries in the body leading to lower blood pressure.
Let me know if you have more questions.
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Kind regards
Expert:  Dr. Thomas, MD replied 1 year ago.
Hello
I disagree.
HCTZ has no significant dilation effect on the arteries.
The mechanism is through effects on the kidneys, and increased water loss; other mechanisms are only poorly understood, and direct vasodilation is only postulated as a possible action.
See here
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904515/
Expert:  Dr. SH replied 1 year ago.
Let me know if you have more questions.