This is Dr Basu, Experienced Specialist.
I am here to address your concerns and provide great service.Panniculitis
is the inflammation of th subcutaneous fat layer causing nodule formation.
This can be due to the host of factors.
Infection, Inflammation, deposition, or malignancy can cause panniculitis.
Lupus is an example of autoimmune
Gout is an example of depository disorder.
T cell lymphoma is a skin manifestation based malignancy.
Pancreatitis and AAT deficiency also can cause panniculitis.
Yes biopsy is required.
But a thorough evaluation for above causes also required.
Thank you for sharing your concerns with us today. If you have any additional questions or need further clarifications, please do not hesitate to ask. I am here to answer them. I wish you good health. Regards, ***** *****