I have a fair amount of anxiety about this. I have celiac disease, interstitial cystitis and thyroiditis, so I am very careful about what I take, either over the counter or prescribed. I have actually had the pain for 8 years, for the most part the core issue is undiagnosed, but since a colon resection in July, it has returned with a vengeance accompanied by symptoms of levator ani. I have been in bed for almost four months, and was first given hydrocodone which did little for the pain and the idea of possible liver complications worried me. But I have a business, a husband, grandchildren, and I was so tired of not having a life that I agreed to try the oxycodone, which I did for a week at the 7.5 mg. dosage. I have now been on the extended release for a week and am not experiencing the same relief. The doctor at the pain management clinic did tell me that it would take 72 hours to take full effect. The pain is significant enough that the short-duration dose only took away about 70% of the pain, but I have spent 8 years with a pain level of about a 3 - 4 daily, so that I can live with. Now with the extended-release at 5mg. I am experiencing only about 50% pain relief which leaves me tired and back in bed at about 4 p.m. each day. I am also concerned as my colo-rectal surgeon wants me to begin Yoga, I need to have physical therapy for the levator ani, and with a 50% pain level, those are not things I can undertake. Was my doctor at the pain clinic starting me out conservatively compared to my previous dosage? Or are they essentially equal, and I should be experiencing the same relief? I am asking a doctor from outside my sphere of treatment because I was so intimidated by my treatment at the pain clinic. I understand that the government is regulating these prescriptions more closely, but as a conservative woman who has never taken drugs I was astounded to be treated like a drug addict, and basically I felt that when I signed their forms I was committing myself to being labeled as a drug addict forever. I had to submit a urine sample on my first visit, and was asked twice by the assistant if I had taken anything else, valium, flexorell, etc besides the oxycodone that day. And I caught her looking over my shoulder into my purse when I opened it to pay! I don't know, Dr. Robert, if I am afraid to ask them these same questions, or tell them how I feel, maybe this clinic is not the right fit for me!