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I am Mysticdoc, experienced Internal Medicine Specialist.
I am here to help you with your concerns.
I understand your confusions.
IgG3 is a subset of IgG antibodies produced by the the white blood cells, lymphoid tissues.
In some individuals like yours there can be genetic defect resulting in defective IgG3 production.
IgG3 deficiency results in recurrent sinopulmonary infections with streptococcal, and M catarrhalis bacteria.
These bacterial infection can be prevented by the pneumococcal vaccines in most cases and also with prophylactic antibiotics.
But in some individuals, this may not be sufficient.
In that case, Immunoglobulin infusion is suggested every 4 weeks for 1-2 yrs.
After 1-2 yrs, your response should be re evaluated.
In most cases the treatment can be stopped at that time.
In some cases, the treatment may need to be repeated in future.
But life long treatment is not usually required.
You can get more information in the following link:
Please reply here if you have any further question.
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Is this deficiency always caused by hereditary means? Before I went to Saudi Arabia with the US Air Force back in 1992, one month prior to going to Saudi troops had to get a "GG shot" and ever since I went to Saudi I have gotten chronic sinus infections and bronchitis. Later the day I got the shot, I got the first and worst headache of my life which turned out to be the onset of me getting migraine headaches to which I still get two migraines a week which usually last 2-3 days each; so, I pretty much always have one... just to varying degrees. Could this shot have triggered the onset of this deficiency and/or activated the disease in me and with the migraine reaction to just the "GG shot" would the gG infusions result in more migraines for me or does the deficiency perhaps cause the migraines? And, thank you for all of the previous information you have given me on this subject as I am very pleased with the info and website you provided me.