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If I have been on diazepam 10 mg 4 times daily for years, and

Customer Question

If I have been on diazepam 10 mg 4 times daily for years, and wean myself down daily to none in 2 weeks, then for how long will I still test positive for benzodiazapines?
Submitted: 1 year ago.
Category: Medical
Expert:  Dr. Vikas replied 1 year ago.

Dr. Vikas :

Hello,

Dr. Vikas :

Any medicine may persist in the body for 4-5 times its elimination half life after the last dose taken. The elimination half life of Diazepam is 20-50 hours.

Customer:

So after the last dose I am looking at 250 hours after the last dose?

Dr. Vikas :

although a lot also depends on other factors like body weight, duration of use, physical condition but in most cases the drug is completely flushed out from the body within 10-14 days if we consider its elimination half life of 20-40 hours.

Dr. Vikas :

yes

Customer:

OK, thank you.

Dr. Vikas, Doctor
Category: Medical
Satisfied Customers: 2219
Experience: MBBS; MD
Dr. Vikas and 8 other Medical Specialists are ready to help you
Expert:  Dr. Vikas replied 1 year ago.
Lee,

I have not finished yet. Please note that "Urine concentrations of metabolites are detectable for several days to weeks after last use. Urinary excretion of unchanged drug is less than 1%.

source - Drugs and Human Performance FACT SHEETS - Diazepam

http://www.nhtsa.gov/people/injury/research/job185drugs/diazepam.htm
Expert:  Dr. Vikas replied 1 year ago.
Please also see this link below.


In chronic users, it may take few weeks (1-6 weeks or more)and till then the medicine can be detected in urine.

Please see the link below for more information.


http://www.passyourdrugtest.com/timetable.htm


The main reason behind this is because " The initial distribution phase is followed by a prolonged terminal elimination phase (half-life up to 48 hours). The terminal elimination half-life of the active metabolite N-desmethyldiazepam is up to 100 hours. Diazepam and its metabolites are excreted mainly in the urine, predominantly as their glucuronide conjugates."

source - http://www.rxlist.com/valium-drug/clinical-pharmacology.htm

I hope this helps, please feel free to discuss further if you have any doubt or other question in your mind.

Kind regards

Vikas

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