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Dr. Thomas, MD
Dr. Thomas, MD, Board Certified Physician
Category: Medical
Satisfied Customers: 56430
Experience:  Internal Medicine--practice all of internal medicine, all ages, family, also Integrative, CAM, etc
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The combination of amitriptilne and gingobiloba is hepatoxic

Resolved Question:

The combination of amitriptilne and gingobiloba is hepatoxic but it is extremely important important to my health welfare and very survival.With your advice I am considering taking a chance.Do you think it could be life threatening
Submitted: 1 year ago.
Category: Medical
Expert:  Dr. Thomas, MD replied 1 year ago.

DrThomasMd :

hello from ja

DrThomasMd :

what source?

DrThomasMd :

are you there?

DrThomasMd :

The main problem is that gingko will speed up how fast amitriptiline is processed by the liver

DrThomasMd :

It is not necessarily hepatotoxic

DrThomasMd :

I am still not seeing any responses from you

Customer:

yes does that mean there will be less antidepressant effect I am not concerned

DrThomasMd :

Yes

DrThomasMd :

less effect

DrThomasMd :

but your doctor can monitor and compensate for that.

DrThomasMd :

And can monitor liver enzymes

DrThomasMd :

Make sense?

Customer:

if there is toxicity will I get any early warning symptoms

DrThomasMd :

Not necessarily, that is why the doctor should do labs every 3 months for one or two times, then every 6 months, but as far as we know, the problem is not toxicity, but making the liver process your elavil faster

Customer:

shouldi have a blood test for liver enzymes

DrThomasMd :

That is what I said

DrThomasMd :

Yes

DrThomasMd :

Gingko is not know for liver toxicity

DrThomasMd :

There is some concern with an increased risk of seizures with this medication.

DrThomasMd :

With the combination.

DrThomasMd :

That is again presumably due to an effect on elavil metabolism

DrThomasMd :

So a normal side effect risk might be increased.

Customer:

I know you are a ssceptic of the internet but it says there is unususal bleeding in vital organs and organ hepatoxicitiy and possibly convulsions

DrThomasMd :

I am using FDA information

DrThomasMd :

Take a look

DrThomasMd :

Close monitoring by your doctor

DrThomasMd :

If your doctor agrees

DrThomasMd :

you can probably do this.

DrThomasMd :

However, there is presumed risk

DrThomasMd :

Other sources say no interactions.

DrThomasMd :

So it is not a high interaction combination.

DrThomasMd :

These are possibilities

Customer:

what is Elavil metabolism?

DrThomasMd :

how your liver breaks down amitryptalline

DrThomasMd :

Amitryptalline is elavil

Customer:

thank you very much you are a life saver

DrThomasMd :

No problems, find me anytime for any question.

DrThomasMd :

Please don't forget a positive rating, or we are not paid by ja

Dr. Thomas, MD, Board Certified Physician
Category: Medical
Satisfied Customers: 56430
Experience: Internal Medicine--practice all of internal medicine, all ages, family, also Integrative, CAM, etc
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