How JustAnswer Works:
  • Ask an Expert
    Experts are full of valuable knowledge and are ready to help with any question. Credentials confirmed by a Fortune 500 verification firm.
  • Get a Professional Answer
    Via email, text message, or notification as you wait on our site.
    Ask follow up questions if you need to.
  • 100% Satisfaction Guarantee
    Rate the answer you receive.
Ask Dr. David Your Own Question
Dr. David
Dr. David, Board Certified Physician
Category: Medical
Satisfied Customers: 42259
Experience:  Experienced Physician trained in New York City. I'm ready to help.
Type Your Medical Question Here...
Dr. David is online now
A new question is answered every 9 seconds

does oxymorphone or opana er accumulate in your system making

This answer was rated:

does oxymorphone or opana er accumulate in your system making an overdose more likely. If not how much of either would cause an overdose?
Hello, this is Dr. David. I have read your question and am ready to help.

opana (oxymorphone) does not accumulate in the system. every 7-12 hours the dose of oxymorphone is cut in half in your body so in 35 hours to 60 hours, the medicine is completely out of your system. it is a very slow acting and long acting medication because of this long 1/2 life.

the overdose for mice that kills 50% of mice is about 400mg/kg of mice.

so for a regular human of 70kg would be 28,000mg of opana.

so you shouldn't be scared of overdosing from opana.

let me know if you have questions.
Customer: replied 3 years ago.

thank you but I have one last question. what does a concentration of 286 ng/ml mean on an autopsy report? The coroner considered this oxymorphone intoxication.

this is the amount of oxymorphone in the blood per ml of body fluid like blood.

that is 286 nanograms per milligram of fluid.

if the coroner is considering this oxymorphone intoxication then that shows that there was a very high dose of oxymorphone in the body when the patient died.

did the coroner rule that this was the cause of death?
Customer: replied 3 years ago.

yes he did we are just trying to figure out how many pills at 5mg he would had to have taken to get to that concentration


Thank you so much for your reply

40 mg of opana results in a peak concentration in the blood of

2.50 ng/ml


so you need 40mg x 114 or 4576mg of opana or possibly 915 5mg pills could have been ingested.


see the info here

Dr. David and other Medical Specialists are ready to help you

Related Medical Questions