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Hello and thank you for the question. Answers given are for informational purposes only and are not meant to replace an exam by an in-person.I am Dr. Sohaib, a practicing Internal Medicine Specialist and i will do my best to help you today.
In general, this is a very well tolerated drug and many of my patients have been using these for years and years with out reporting any side effect.
But as described in literature, side effects can happen with any drug (even with the commonly used tylenol) and one should be cautious about these. Whenever a drug is prescribed for long term use, self monitoring is the best strategy to report any kind of unusual effects to the doctor at earliest.
Here is one such useful link where you can read about the common side effects and interaction of singulair (montelukast);
I hope this will be of great help to you.
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Does its effectiveness vary over time?
The effectiveness varies from one person to another.
During different phases of illness (more effective in preventing an attack rather than during an acute attack of asthma).
No, the effectiveness is not reduced rather it is one of the few drugs whose efficacy in treating asthma is well documented when used long term.